Curious about the varying cannabis types, the health benefits and risks, and the physiological effects? Learn more about cannabis and its application in healthcare and the risks associated with this plant that is growing in popularity every day.
Cannabis is a flowering plant indigenous to Central Asia. There are three common classifications – cannabis sativa (c-sativa), cannabis indica (c-indica) and hemp, which is a sub-type of c-sativa . Cannabis is cultivated for use in a variety of commercial products including food, medicine, nutrition, clothing, textiles, biofuel, food, animal feed, cordage, building materials, and plastics (1). The plant material (stock, stem, seed, leaf, etc.) is primarily used for industrial products, while the oil extract (cannabinoids and terpenes) is primarily used in nutritional and medicinal products.
The 3 Cannabis Types
A pure c-sativa plant may grow 4-8 feet high and has a long stem and large narrow-bladed leaves. It produces a long narrow bud and typically has lower tetrahydrocannabinol (THC) content and higher cannabidiol (CBD) content (6).
A pure c-indica plant may grow 3-4 feet high and is bushy with short, wide leaves. It produces a wide dense flower and typically has a higher THC content and lower CBD content (6).
Hemp is a subtype of c-sativa and may grow to be 10-12 feet high and has a thick stock, long stem, and long narrow leaves. Hemp has a very low THC content and a high CBD content and has long been cultivated for the industrial use of its plant material and biomass.
Health Benefits of Cannabis
Although cannabis is cultivated for a variety of uses, the health benefits of its oil extract have taken center stage over the last few years. Researchers have been able to identify over 113 different cannabinoids and over 100 different terpenes that are produced by the cannabis plant (5). The most well-known compounds are cannabidiol (CBD) and tetrahydrocannabinol (THC). These compounds are found in all types of cannabis plants, and through selective breeding, cultivators can produce plants with different concentrations of CBD and THC.
Cannabidiol – CBD is the most abundant cannabinoid found in the cannabis plant. It makes up about 40% of the cannabinoid extract produced by the plant (2). CBD can be administered through oral ingestion, inhalation, nasal spray, topical lotion, or suppository.
Administration & Dosage of CBD
When administered orally about 15% of the drug will make it to the bloodstream unchanged. When inhaled this number doubles to around 30%. This is known as bioavailability, which is the percentage of the drug in the bloodstream that remains unchanged after administration. The half-life of CBD is reported to be about 9 hours, which means that 50% of the drug has been eliminated from the body after 9 hours of its administration. The half-life and bioavailability of a drug are important factors in determining the dose, route, and frequency of use.
How CBD Interacts With Your Body
CBD interacts with neurotransmitters and endocannabinoid receptors found in the central nervous system, peripheral nervous system, immune system, and spleen (9,12). The extent of this interaction is not fully understood, however current research suggests that CBD partially binds with CB1 receptors found in the basal ganglia, limbic system, hippocampus, and with CB2 receptors found in the immune system and spleen (8,12).
The physiological effects produced by the binding process are what make CBD medically beneficial. CBD is reported to help reduce the symptoms of nausea, anxiety, inflammation, and muscle spasticity (10). Additional studies report conclusive evidence that CBD acts as a neuroprotective antioxidant (24,25). CBD recently gained approval by the Federal Drug Administration (FDA) as an anticonvulsant for the treatment of two rare forms of epilepsy.
Research also indicates CBD is a serotonin 5-HT1A receptor agonist. The 5-HT1A receptor impacts several physiological functions in the body including modulation of serotonin and dopamine, which may explain CBD’s reported anti-anxiety and anti-depression benefits (4).
Additional research suggests that CBD is an antagonist to THC, which means it inhibits THC from binding with neurotransmitter receptors. By doing so, CBD may counteract the common side effects of THC use, which may include short-term memory loss and cognitive impairment (11). Studies indicate CBD is well tolerated with reported side effects that may include diarrhea, tiredness, or change in appetite (13).
How THC Interacts With the Body
Tetrahydrocannabinol – THC is a fat-soluble cannabinoid found in the cannabis plant. It is the primary compound that causes the psychoactive (high feeling) effects associated with cannabis use. It can be administered through oral ingestion, inhalation, topical cream, transdermal patch, nasal spray or suppository.
When THC enters the bloodstream it makes its way to the brain and binds with cannabinoid receptors primarily located in the central nervous system. These receptors are prevalent in areas of the brain that affect body coordination, learning, memory, stress control, higher learning, cognitive function, emotional response, fear, peripheral sensations, sleep, and nausea (23).
THC has an elimination half-life range of 2-48 hours and its bioavailability is estimated to be 10-35% when administered through inhalation and 6-20% when taken orally. Users often report more intense reactions to THC when taken orally. This is most likely due to enzymatic changes to the THC compound that occur during the digestive process resulting in either increased receptor affinity or increased bioavailability of the THC compound. In most cases, users report a significant reduction in the effects of THC after 2-8 hours of administration. This time will vary depending on the amount and manner of administration, the frequency of use, and the tolerance level of the user (14,15).
Studies suggest that THC in combination with CBD may be effective in reducing muscle spasticity, centrally mediated pain, and painful spasms. There is also sufficient evidence to suggest that, THC combined with CBD, acts as a neuroprotective antioxidant within the body and that these antioxidant properties were demonstrated to be superior to the antioxidant properties of vitamin E and vitamin C (24,25).
Potential Negative Impact of Short- and Long-term THC Usage
Cannabis intoxication in association with short-term use of THC has been shown to negatively impact memory, attention span, and physical motor skills (19). Long-term use of THC has been shown to have similar negative effects and may result in habituation requiring the user to increase the strength and quantity of THC to obtain the desired effect.
Recent studies report that 10-20% of cannabis users become dependent (17). Dependency is different than addiction and is classified by the Diagnostic and Statistical Manual of Mental Health Disorders (DSM) as “Cannabis Use Disorder” (18). Cannabis dependency is reported to be less severe than that observed with cocaine, alcohol, or opiates (20). Studies suggest strongly that early age onset and long-term use of THC may contribute to mental health problems and physical and motor disorders (21). And most recently, a 2017 study reported clear evidence that long-term use of cannabis increases the risk of psychosis (22).
Use Cannabis Appropriately for Health Benefits
The cannabis plant is a rich and diverse resource and can be used in over 2500 different commercial products. As more research demonstrates the health benefits of CBD, its use in the medical and supplemental health markets has been on the rise in the US over the last decade.
The FDA recently approved a cannabis-derived drug produced by GW Pharmaceuticals for the treatment of two rare forms of epilepsy. This is a big step forward in the area of cannabis research and development, which may bring about the expanded and more targeted use of cannabinoids, for the treatment of medical conditions.
It is clear that not all cannabinoids are beneficial. The long-term use of THC has been shown to have significant adverse effects and often results in habituation and dependency. This is especially true with early age onset of use. This is an alarming fact as more states approve medical and recreational cannabis. As the drug becomes more commercially popularized its use will likely increase amongst the younger population.
While regulated use of cannabis for medical purposes offers patients suffering from chronic conditions additional treatment options; recreational use for increasing a state’s tax revenue seems reckless given the potential downside associated with early-onset use, the adverse effects of long-term use, and the unknown social consequences associated with more users.
If you or a loved one is interested in medical marijuana for a chronic condition and live in the State of Florida, contact THC Physicians to learn more about how it may help.
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