Chronic Pain

Medical marijuana for chronic non-malignant pain

Medical marijuana for chronic non-malignant pain (CNMP) is quickly becoming a popular option amongst patients and doctors for a multitude of reasons. Recreational cannabis has widely been cited by chronic pain patients for pain care, and with the legalization of medical cannabis, many doctors are enjoying its benefits for their ailing patients as well.

Many traditional pharmacological pain treatments are only nominally effective (1). What’s worse, these treatments are commonly associated with addiction and potentially death, an overdose with opioids -- a common chronic pain treatment -- have been considered a “crisis” in the United States (2).

With new and existing research available on the use of medical marijuana for chronic non-malignant pain, we examine some of these findings that highlight why one in five CNMP sufferers are trying medical cannabis as a viable option for pain treatment.


Chronic Pain Sufferers Report  Pain, Sleep and Mood Improvements with Cannabis Use

In a comprehensive study on cannabis use for chronic non-cancer pain (3), 209 pain patients were anonymously recruited to examine the effects of the drug on their pain. Of those patients, 72 patients reported having used cannabis, 32 reported using cannabis for pain relief, and 20 subjects reported that they were currently using cannabis for pain relief. 38 subjects said they did not use cannabis for pain relief. The largest group of patients that used cannabis had neck or upper body pain caused by trauma or surgery.

For the subjects that reported cannabis usage for their ailments, pain, sleep and mood were the issues that they said were improved with use. This study showcases the prevalence of cannabis use amongst the chronic pain population and the self-reported benefits of using the drug.

Medical Marijuana Shown Effective in Chronic Pain, Neuropathic Pain, and Spasticity due to MS

Harvard Medical School published a study, Medical Marijuana for Treatment of Chronic Pain and Other Medical and Psychiatric Problems: A Clinical Review (4), that found “marijuana or cannabinoids may be efficacious for these indications.”

The study, which reviewed evidence from 1948 to 2015, evaluated 28 randomized clinical trials using cannabinoids as pharmacotherapy. Of the evidence reviewed, five out of the six neuropathic pain studies and six out of six general chronic pain studies showed significant improvement in the patients’ symptoms.

Cannabinoids and THC Shown to be Significant in Trials on Neuropathic Pain, Fibromyalgia, Rheumatoid Arthritis, and Mixed Chronic Pain

In another study conducted to evaluate the effectiveness of cannabinoids for chronic non-cancer pain (5), researchers studied the effectiveness of smoked cannabis, oromucosal extracts of cannabis based medicine, nabilone, dronabinol and a novel THC analogue. The review of trials included patients who suffered neuropathic pain, fibromyalgia, rheumatoid arthritis, and mixed chronic pain.

Of the 18 trials that met the inclusion criteria of the study, 15 “demonstrated a significant analgesic effect of cannabinoid as compared with placebo and several reported significant improvements in sleep.”

The study also reported no serious adverse side effects.

Medical Marijuana used as an Adjunct to Opioids

Research has also been done to compare the effectiveness of medical marijuana as an adjunct to opioids (6). Of the six trials conducted, five of them were considered to be of high quality with researchers concluding “evidence for the use of low-dose medical marijuana in refractory neuropathic pain in conjunction with traditional analgesics.”

The study evaluated smoked cannabis and vaporized cannabis.


As referenced above, many of the studies on medical marijuana and chronic non-malignant pain conclude the drug has very few adverse side effects.

However, the research does include some cautionary advice. In the Canadian ScienceDirect study mentioned above, there was considerable variability in the amounts of cannabis used for treatment. As with other studies, the best rule of thumb seems to be to start with low dosage as higher doses can actually make pain worse.

In the study evaluating pain from multiple sources, no serious adverse events were reported but minor adverse side effects included sedation, dizziness, dry mouth, nausea and disturbances in concentration. Other adverse events included “ poor coordination, ataxia, headache, paranoid thinking, agitation, dissociation, euphoria and dysphoria.”

Compared to the side effects of opioids -- a commonly prescribed CNMP drug -- which were responsible for the deaths of more than 42,000 people in 2016, the adverse effects of medical marijuana are minor.


Chronic Non-Malignant Pain or CNMP, as defined by the International Society for the Study of Pain, is unpleasant sensory and emotional experience associated with actual or potential tissue damage. CNMP lasts three months or more and can begin with disease, trauma, or can occur de novo. The pain can become progressively worse and reoccur intermittently, outlasting the usual healing process. After injured tissue heals, pain is expected to stop once the underlying cause is treated, according to conventional ideas of pain.

The assessment of CNMP starts with an assessment of your history and a physical evaluation, a pain evaluation, and functional and social assessment tools.

Medical marijuana for chronic pain evalution process


Traditional Chronic Non-Malignant Pain Treatment Options

According to the American Academy of Family Physicians, “Evidence of the effectiveness of most treatment options is lacking or inconsistent.” It should be noted that they do NOT include medical marijuana in their list of treatment options, although evidence suggests otherwise.

These treatments include, but are not limited to:

  • Lifestyle changes
  • Physical changes such as exercise or therapy, stretching, surgical therapies
  • Psychologic treatments
  • Alternative treatments such as acupuncture or massage
  • Occupational therapy
  • Pharmacologic treatments such as:
    • Nonopioid analgesics
    • Opioid medications
    • Adjuvant medications

It should be mentioned again that many physicians recommend a strong patient reluctance to use opioids due to concerns with abuse, addiction, and adverse side effects.

Trying Medical Marijuana Treatment for Chronic Non-Malignant Pain

Patients with Chronic Non-Malignant Pain have shown positive results with the usage of medical marijuana. If you are interested in trying medical marijuana for Chronic Non-Malignant Pain or are inquiring for a loved one, you should first seek out your state laws to determine the legality of the drug in your state, the types of medicine you can use, where to get it, and how much you need.

If you are located in Florida, check out THC Physicians for your medical evaluation, the first step in getting a Florida Medical Marijuana Card.



Howard Seth Meiselman, DO

Medically reviewed by Howard Seth Meiselman, DO — Written by Mark Conklin: Editorial Process