CBG vs CBD: What Are The Differences?

Last Updated on May 23, 2022 by Mark Conklin, RN, MHA

You’ve likely heard of tetrahydrocannabinol (THC) and cannabidiol (CBD). But did you know many other cannabinoids exist? There are over 100 identified cannabinoids in marijuana, many with different effects on the body.

CBG is rising in popularity as a notable anti-inflammatory and antioxidant. 

Let’s dig a little deeper into CBG vs CBD, the different feelings you’ll get taking them, and what sets them apart in the realm of ailment easement. We’ll also tell you the best way to get CBG.

What is CBD?

You’ve likely heard of CBD, so we’ll keep this brief. CBD is the compound found in marijuana or hemp that is lauded as a medicinal savior. It’s known to help with inflammation, anxiety, seizures, pain relief, and acne, among other conditions and ailments.

You can read more about CBD here: The Health Benefits of CBD with Key Scientific Research to Back Them.

What is CBG?

CBG stands for cannabigerol. First discovered in the 1960s, it is considered a minor cannabinoid due to its minuscule amounts found in cannabis and hemp plants.

What are the benefits of CBG?

CBG can be used to treat a variety of medical conditions. Anorexia, IBS, skin conditions, osteoporosis, insomnia, pain, and seizures are among a few. Some of the benefits of CBG include:

  • pain relief
  • antibacterial properties
  • appetite stimulant
  • seizure reduction
  • reduced inflammation
  • bone growth stimulant
  • sleep aid
  • cancer cell growth inhibitor
  • brain cell stimulant

CBG is the “Mother” of Cannabinoids

CBG begins as CBGA or cannabigerolic acid. As with many chemical compounds, heat, light, and oxidation can cause molecules to change. As the molecules transform into their neutral form, the CBGA turns to CBG.

But even though there isn’t a lot in the plant, CBGA is often referred to as the “mother” of cannabinoid acids because CBGA is the one from which all other cannabinoids are produced. 

The CBGA can convert to CBG, but it can also morph into THCA (tetrahydrocannabinolic acid) or CBDA (cannabidiolic acid), among other cannabinoid acids. Once these acids form from CBGA, they go on to become THC and CBD. 

With age, these chemicals turn into other cannabinoids like CBN and Delta-8 THC. But we’ll save the explanation of CBN for another time. Let’s talk CBD vs CBG.


For us to explain what makes these two cannabinoids different, you’ll need first to understand what happens in your body when you consume one of them.

Your body has it’s very own endocannabinoid system (ECS) and creates and processes its own type of cannabinoids for homeostasis.

The ECS is made up of receptors that bind to internal and external cannabinoids and enzymes to break them down. 

The two receptors are CB1 and CB2 receptors, located in different parts of your body. The receptor’s location to which the cannabinoid binds is what ultimately determines how the compound affects your body.

The ECS is responsible for regulating memory, sleep, metabolism, appetite, stress, mood, and more.

CBD has an indirect effect on the ECS. Many experts believe that it works by preventing natural endocannabinoids’ breakdown, allowing them to have a longer-lasting impact on your body. Others even believe there is a receptor that CBD binds to that has yet to be discovered.

Alternatively, CBG is believed to bind to both CB1 and CB2 receptors, preferring the CB2. The CB2 receptors connect the peripheral nervous system, which means it has numerous benefits for muscles, limbs, and skin. 

In a 2014 study of CBG in rats, researchers found that the compound may reduce the rate at which cancer cells multiply. 

While a vast amount of research has been done on CBD, consumers are only just beginning to recognize the health advantages of CBG. Additional studies need to be performed to understand the full spectrum of benefits.
Neither CBD nor CBG has psychoactive properties, as THC does. In fact, both compounds counteract some of the adverse effects of THC, such as paranoia.

Where to Buy CBG

CBG is tough to find in its purest form, and when you find it, it’s often expensive. Not only is it a relatively newer trend, but it’s also difficult to produce. It’s often dubbed “the Rolls Royce of cannabinoids”.

According to ACS Laboratory, which does cannabis lab testing, “CBG is extracted through a chromatography process that uses super-fluid liquid solvents like CO2 or ethanol to extract the cannabinoid. During the extraction process, hemp is dissolved in the solution, which draws the cannabinoids and terpenes out of the plant. The solution is then evaporated with heat under a vacuum to remove all the gas and leave a high purity CBG concentrate behind.”

Full-spectrum CBD oils that are marijuana-derived (rather than hemp-derived) are a great way to get the benefits of CBG since the original cannabinoids stay intact. These include THC, so it does require a medical marijuana card in many states. 

If you live in Florida or New York, you can see if you qualify and obtain one quickly and easily here

Many medical conditions can permit you to get a medical marijuana card. These include chronic pain, cancers, epilepsy, HIV/Aids, Inflammatory Bowel Disease, MS, Parkinson’s, PTSD, and more.

If you have any questions please contact THC Physicians. If you live in New York or Florida, feel free to visit THC Physician to see if you qualify for a card today.

Howard Seth Meiselman, DO

Medically reviewed by Howard Seth Meiselman, DO — Written by Mark Conklin 

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Mark Conklin, RN, MHA

Mark Conklin is the founder and CEO of Tierra Healthcare Concepts and is also part of the medical team. He has over 25 years of experience in the healthcare field working at the executive management level and as a medical professional. Education RN, BS Biology, and Master of Health Administration course curriculum.

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